Tweedy Browne acquired 2.89M Ionis Pharmaceuticals shares worth $172M. It makes up 15.35% of their stock portfolio and is their biggest holding. The investor owns 2.53% of the outstanding Ionis Pharmaceuticals stock. The first Ionis Pharmaceuticals trade was made in Q1 2022. Since then Tweedy Browne bought shares one more times and sold shares on nine occasions. The stake costed the investor $101M, netting the investor a gain of 71% so far.